What was the primary endpoint of the SUNBURST study?

The primary endpoint of the SUNBURST study was to demonstrate the non-inferiority of burst stimulation compared to tonic stimulation. This means the study aimed to show that burst stimulation was not worse than tonic stimulation in terms of effectiveness. Non-inferiority trials are important in assessing new treatment approaches, as they help determine if the new method provides comparable benefits without being significantly less effective. This focus on non-inferiority allows researchers to potentially support the use of a new therapy while maintaining existing standards of care.

The emphasis on non-inferiority is particularly relevant within clinical research when introducing alternative modalities, such as burst stimulation, which may have different side effects or mechanisms but are expected to provide similar outcomes to established techniques like tonic stimulation.